Comprecel MCC (Microcrystalline Cellulose) is a pharmaceutical excipient derived from nature's most abundant and renewable raw material-wood pulp. FIRST AID MEASURES Eye Contact Hold eyes open and rinse slowly and gently with water for 15 to 20 minutes. PDF (2.77 mb) 2021 FMC Sustainability Report. Millipore. Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). The table below lists the most important chemical identifiers applicable to Avicel Microcrystalline cellulose. The figure below illustrates the structural organisation of cellulose within plants. Find answers in our support articles. FMC Corporation. . ECOLOGICAL INFORMATION ECOTOXICITY Practically nontoxic to fish: Rainbow trout LC50 (96hr) > 100%, saturated solution (Microcrystalline cellulose, Avicel PH-101) PERSISTENCE AND BIODEGRADABILITY Inherently biodegradable. Product Name: Microcrystalline Cellulose 1.2. 2021 Annual Report. B;vLZpHU%ChUyD+[ In Cellulose and Cellulose Derivatives in the Food Industry, T. Wstenberg (Ed. Molecular weight: Not Applicable 1.5. endobj P}MFbN#[>r(y Carrageenan is a naturally occurring family of hydrophilic polysaccharides extracted from several closely related species of red seaweeds. Material safety data sheet - FMC Corporation. 4 0 obj MATERIAL SAFETY DATA SHEET Avicel PC 611 Microcrystalline Cellulose Page 1 of 8 MSDS Ref. 1. Microcrystalline cellulose is an exceptional material and one of the most widely used excipients in the pharmaceutical field. <> /MediaBox [0 0 612 792] microcrystalline cellulose and carboxymethylcellulose sodium NF, Ph. Microcrystalline Cellulose (MCC) MSDS 1. >> Eur., JPE . Microcrystalline cellulose 9004-34-6 <1 Synonyms are provided in Section 1. We can send by Fedex, by ship or by plane according to international rules. Created Date: 2/10/2020 8:51:41 PM . Material Safety Data Sheet or SDS for Cellulose microcrystalline 102331 from Merck for download or viewing in the browser. Buy Chemicals. Carboxymethyl Cellulose Sodium N/A Nutrition & Biosciences www.pharma.dupont.com HO 00017 - 0 E L 02.2020 www.dupontnutritionandbiosciences.com . A., and Smith, P. A. SUBSTANCE IDENTIFICATION 1.1. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. 4 0 obj INCI. Unique functionality for a broad range of pharmaceutical applications. stream q86@on$^X_HuH;3` ?t#_n|z%4n#(!:lMD~{mfvv}Na0vx?? Assay for carboxymethycellulose sodium, wt % 8.3 to 13.8 . 2008-2023 ChemPoint. Microcrystalline cellulose -The oldest polymer finds new industrial uses,. Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 April 21st, 2019 - Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 Section 1 Chemical Product and Company Identification Ethanol has been shown to produce fetotoxicity in the embry o or fetus of laboratory animals Prenatal Chemical waste generators must determine PDF (28.38 mb) 2022 Corporate Fact Sheet. % Delivering efficient and robust formulations. All Rights Reserved. Alginates from IFF are an excellent choice for consistent performance in a variety of applications. The chemical structure of cellulose is shown below: In the biosynthesis of cellulose, two molecules of -D-glucose molecules combine via a condensation reaction (elimination of one molecule of water) to form the so-called cellobiose unit. They are made up of sulfated and non-sulfated repeating units of galactose and 3,6-anhydrogalactose. Document(s): certificate data msds. Avicel Microcrystalline Cellulose is a safe and non-hazardous material that is widely used in pharmaceutical formulations and food products (as a bulking agent and to add crispness). pH 6.0 to 8.0 . Frijlink, Compaction mechanism and tablet strength of unlubricated and lubricated (silicified) Microcrystalline Cellulose, European journal of Pharmaceutics and Biopharmaceutics, 59 (2005) 133-138. stream <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 6 0 R/Group<>/Tabs/S>> Explore how we work and why we apply science and creativity for a better world to everything we do. Microcrystalline cellulose (C6H10O5)n is refined wood pulp. GRINDSTED Xanthan Gum readily dissolves in water under ambient conditions without the need of special high-shear equipment. Further elaborations can then be performed on the obtained material to produce many other grades of Microcrystalline cellulose. Truly distinctive drug delivery solutions. msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, It is, however, a good source of fibre. LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such as non-stick coatings, insulation of wiring, crop protection and paints,coats and inks. JFIF ` ` ZExif MM * J Q Q Q C The UK Health & Safety Executive has set workplace exposure limits at 10 mg/m3 long-term (8 hr TWA) for total inhaled dust and 4 mg/m3 for respirable dust. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. F. Lerk, G.K. Bolhuis, A.H. De Boer, Effect of Microcrystalline Cellulose on liquid penetration in and disintegration of directly compressed tablets, Journal of Pharmaceutical Sciences, 68 (1979) 205-211. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes. The global Microcrystalline Cellulose (Mcc) market size is projected to reach multi million by 2026, in comparison to 2022, at unexpected CAGR during 2022-2026. Are you sure you want to delete your template? {iy7uEijn0y]"s"gbV~p8Q)zN:cyvs]&,kk=6pcA %iBW|2nKa)Jb7` 0 endstream endobj 524 0 obj 458 endobj 525 0 obj << /Filter /FlateDecode /Length 524 0 R >> stream Hi, let us know if you have any questions as you visit our website. Manufacturer: FMC BioPolymer. To help, weve put together a simple guide for selecting Avicel Microcrystalline cellulose grades, with simple explanations of some of the most common grades, plus recommendations that will serve the majority of buyers. Foam Booster/Stabilizer; Rheology Modifier; Stabilizer-Emulsion; Suspending Agent . 0.25 - 0.37. Material safety data sheet (MSDS) of the m icrocrystalline cellu lose (MCC) Avicel PH-101. Chemical Formula: (C6H10O5)n 1.4. The typical mean particle size is 20200 m. : 1. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication. >z+{!A6wy @nLK3R#hRn sba3;b61V:#Z3X,*?RC!wPmqd7WkA'aZMt6PFV3SEvlY'=p.mn[I{puc\6'ZIyI%rD'zA!"t3I2F ^R;LK,?:&THv*y^K> o0Af?J9J-{s2&cCn)32ADzl%sS5O~J[ In the late 1960s, Avicel Microcrystalline cellulose was registered in the supplement to the National Formulary as a pharmaceutical excipient. Revision No. ( Have an order or account question? MATERIAL SAFETY DATA SHEET. Avicel RC-591 & CL-611 - Description. The process is relatively basic; and starts with treating cellulose, obtained as a high-grade pulp obtained from fibrous plant material, with mineral acids, followed by purification and spray-drying. Trademarks: Avicel PH-102. SDS - Safety Data Sheet. Various Gelcarin and Viscarin carrageenan grades are used by the pharmaceutical industry to achieve specific gelling for controlled drug release, thickening, and stabilizing properties desired in various formulations. In 1964 FMC, Corporation . (Microcrystalline Cellulose Market Pr. However, if handling bulk powders, observance of appropriate safeguards is recommended. The METHOCEL Premium family of water-soluble polymers for pharmaceutical applications offers exceptional flexibility and a broad range of properties typically not found in other water-soluble polymers. The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. Avicel Microcrystalline Cellulose: A Guide to Grades and Uses, Working Hours (Mon to Friday): 08:30 - 17:30, legendary Canadian-born chemist, Orlando Aloysius Battista, United States Pharmacopoeia and National Formulary, United States Food and Drug Administration, Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g), https://doi.org/10.1016/0378-5173(95)04231-8, https://doi.org/10.1016/j.ejpb.2004.05.009, https://doi.org/10.1002/9783527682935.ch04, Pharmaceutical Acronyms and Abbreviations, Glossary of Terms Used in the Pharmaceutical Industry, Standard Terms & Conditions Of Sale Of Goods And Services, 4-O-[(1S)-hexopyranosyl]-D-glycero-hexopyranose. We are artists at heart and creators by nature. undefined. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named 'mechanically disintegrated D.P cellulose. Copyright 2023 by International Flavors & Fragrances Inc. IFF is a Registered Trademark. Regulatory Information There have always been two different points of view for the liquidity of MCC. }[eD-1-8$#Yi^$o8Nc6vwfw;wBT~[Rgi1?%T*/J:/'+Gf'Ae*j@{Rh+2oN|Sbtt;z#v8})F#z=:*]q+U>+ .e ^Q-{@ RPC t/(If>8P&%wNPMJw,VI2aUqRqe3bC,a;C&4RQSf*(=I$r{'%jmk1LUZV(*is6r&wQPAAoID4p?,"lp:wE+)v(_w 'yelVnMh=gIYjK:9v{$G;b8=lGG1_,h^0F2`a~Kusz1p#NS*qt6,F:7+Rma-4u} DINFzJ"Mlctg*~HEge : CL-611NF Date Approved: 01/13/2010. The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed. Chemically, it is an inert substance, is not degraded during digestion and has no appreciable absorption. Avicel Microcrystalline cellulose is manufactured in the United States of America by Dupont. %PDF-1.5 In large quantities it provides dietary bulk and may lead to a laxative effect. It works as a moisture sponge and permits the controlled growth of spheroids. FMC Corporation 2929 Walnut Street Philadelphia, PA 19104 (215) 299-6000 (General Information) . Microcrystalline Cellulose, Colloidal Silicon Dioxide: 50: 0.20 - 0.30: Best in class binder. It flows and compresses extremely well, properties that endear this material wide scope of use in many fields. Watch Now. Avicel RC-591 offers ideal thixotropic bahavior for stabilizing suspensions while Avicel CL-611 is a stabilizer for reconstitutable or dry suspension formulations. Alubra sodium stearyl fumarate from IFF Pharma Solutions is a comparatively hydrophilic lubricant widely used in capsule and tablet formulations. X`I%&/m{JJt`$@iG#)*eVe]f@{{;N'?\fdlJ!?~|? Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. Cellulose, microcrystalline | C14H26O11 | CID 14055602 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . You have already flagged this document.Thank you, for helping us keep this platform clean.The editors will have a look at it as soon as possible. Avicel Microcrystalline cellulose is a type of cellulose, a naturally-occurring, large molecular weight polysaccharide found in woody plants. Pharmacel 112 can be used in a wide range of oral solid dosage (OSD) forms as binder, compressing agent . Standard, 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS . Remove AVICEL RC 581. These, in turn, are assembled into fibrils in the cell wall. These include amphiphilicity, a higher degree of crystallinity, surface area, higher hydration properties, and morphology. The aqueous solution to barrier membrane coating. They are differentiated from each other by the amount of 3,6-anhydrogalactose as well as the number and position of ester sulfate groups present. : 9 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication . Our customers around the world enjoy the benefits of TEXTURECEL NaCMC in various wound care products, too. Comments: The human studies including the use of radiolabelled microcrystalline cellulose show complete absence of digestion or absorption. <> In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. The 'Substance identity' section is calculated from substance identification information from all ECHA databases. 9,LL!z Microcrystalline cellulose 9004-34-6 232-674-9 Not Listed * Magnesium stearate 557-04- 209-150-3 Not Listed * LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. Cellulose is a linear polymer of -D-glucose, linked through carbon atoms 1 and 4. *r_ *?~4$ &0Y# IFF has decades of experience controlling these naturally derived materials, which means you can count on consistent performance, every time. Avicel PC 611 Microcrystalline Cellulose. Avicel PC 611 (FMC Biopolymer) . Fmc Corporation: Ultra-fine microcrystalline cellulose compositions and process . IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1 Product identifiers Product name : Avicel PH-101 Product Number : 11365 Brand : Fluka CAS-No. Watch Now. Patel, F. Podczeck, Investigation of the effect of type and source of Microcrystalline Cellulose on capsule filling, International Journal of Pharmaceutics, 128 (1996) 123-127. There may be more fiber in your food than you realized. This extends the funcionality of microcrystalline cellulose to meet specific viscosity, gelling, suspension and stabilizing properties ChemPoint is an approved supplier of LATTICE MCC in industrial applications, providing dedicated marketing, sales, order fulfillment, and technical support for customers in the EMEA region, Protect and improve AI potency, entrap oil droplets and improve stability, physical barrier that helps suspend particles and breaks down under shear and reforms quickly under rest. This unique functionality can be used in a diversity of applications such as controlled release dosage forms, enteric coatings, microencapsulation and stabilization in solutions and suspensions. Biologicals by FMC. Researcher's newest research report, the "Wood Pulp Based Microcrystalline Cellulose Industry Forecast" looks at past sales and reviews total world Wood Pulp Based Microcrystalline Cellulose sales in 2022, providing a comprehensive analysis by region and market sector of . FMC, JRS and Mingtai were estimated to hold for . l~5C Powder becomes slippery when wet. METHOCEL products have been in continuous production for more than 70 years with production facilities and deep product expertise located around the globe. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named mechanically disintegrated D.P cellulose. : 160182 Date Approved: 05/25/2010 Revision No. United Nations Sustainable Development Goals, Alginates Protanal, Manucol, Protacid and More, Barrier membrane, Controlled release hydrophilic matrix, Taste masking, Carrageenan Gelcarin, Viscarin and More, Controlled release hydrophilic matrix, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Rheology modifier, Rheology modifier/stabilizer, Binder, Controlled release hydrophilic matrix, Rheology modifier, Rheology modifier/stabilizer, Shell - hard capsule, Tablet coatings, Thin films, Topical, Capsules, Other, Solutions, Suspensions, Tablets, Controlled release hydrophilic matrix, Hot melt extrusion, Muco-adhesive, Osmotic pump, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Topical. iq/iVO"5VI}dn.#q^(fJ),BN yb5*4reh1"!E?mR*%fK,e4?A\{OAXr1' tx&Ul{J,57n%PV E2eMS5'UOL wdD{s)4N-m ab K * ~CVHg}{J2.M}O)^}|Z{V+ >AW|? eqgP}OF'v7heLP&Y,eoo`x7lR}0iRVP],=`_2rS'*X$b)+XV2;fbQDgkgx:IZ|v>lDD/TDqz %RL Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives. (1962). It is also used in plaque assays for counting. pfTr^i5wOg)y .6 68ZWN hZB{u7ps@uWm 2#@+o/Z {vd^qHe42)Xz[T|[6:q/ i0lGX*}L[7;SGS "lj@::4G[IN{ Earth Supplied Products LLC. Avicel co-processed grades are co-spray dried blends of Avicel microcrystalline cellulose with synergistic pharmaceutical excipients to yield functional benefits beyond simple physical blends. The MCC can be synthesized by different processes such as reactive extrusion, enzyme mediated, steam explosion, and acid hydrolysis. MATERIAL SAFETY DATA SHEET Lattice NT Microcrystalline Cellulose MSDS Ref. Avicel Microcrystalline cellulose occurs as a white, odourless, tasteless, fibrous powder composed of porous particles. Your file is uploaded and ready to be published. cas:9000-11-7 msds Carboxymethyl cellulose. Microcrystalline Cellulose Side Effects. Avicel PC 611 (FMC Biopolymer) Supplied by. %PDF-1.4 Van Veen, G.K. Bolhuis, Y.S. cas:9004-36-8 msds CELLULOSE ACETATE BUTYRATE. It can be processed both via wet granulation and direct compression, as well as roller compression and extrusion-spheronisation. Ui[(lY[|//o)ZmqbQT-Y.M|se[)m?(WRV.W8J/j}9>X.VNsZNOp'^14nuXM%rea5]@ MKnNe Cellulose microcrystalline Revision Date 25-Dec-2021 SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA - Occupational Safety and Health Administration Not applicable CERCLA Not applicable California Proposition 65 This product contains the following Proposition 65 chemicals. Instead, they obtained a stable colloidal suspension. ChemicalBook. endobj Microcrystalline cellulose in certain fiber supplements may cause mild side effects ().These may include gas, bloating and increased stool production.. This paper is based on a study of the interactions that take place during the process of hydrogel formation, break down, and recovery. : 5. Report Category. %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz /Producer(Sub Systems, Inc.)/CreationDate(D:20211228124915+05'00')/ModDate(D:20211228124915+05'00')/Creator(Sub Systems, Inc.) Molecular Weight null. Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. Synergies to simplify formulation challenges and reduce operational costs. q9;v80q>jZ The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. endobj . LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. Chemical Name Microcrystalline cellulose (INCI Name): MCC, cellulose gel Common Name Avicel PH105 Microcrystalline Cellulose CAS Number 9004-34-6 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice No data available If Inhaled Remove person to fresh air. Microcrystalline Cellulose E460 MSDS 1. . No: 9004-34-6-5 Version: Global Date Approved: 10/16/1998 . 130. JRS Pharma: PROSOLV SMCC 90 LM: Microcrystalline Cellulose, Colloidal Silicon . CAS #: 9004-34-6 . ETHOCEL premium ethylcellulose resins are water-insoluble polymers. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. : 9004-34-6 1.2 Relevant identified uses of the substance or mixture and uses advised against Microcrystalline Cellulose (MCC) Manufacturing Industry. The formed cellulose molecules pack themselves closely to each other, stabilised through hydrogen bonds, creating crystalline regions interspersed with amorphous regions. ( No. Microcrystalline cellulose (Avicel, FMC Corporation) is prepared by acid hydrolysis of cellulose using 2 M hydrochloric acid at 105 C for 15 min. 102331. Microcrystalline Cellulose NF. Production of Pharmaceutical Grade Microcrystalline Cellulose. Microcrystalline cellulose is a commonly used excipient in the . }o]X4]. A family of polysaccharide products that allow distinctive drug delivery solutions. EMCOCEL 90 M. 130. Enter your [postal] code to see information about local products, representatives and retailers, along with special offers in your area. . TEXTURECEL is highly purified sodium carboxymethyl cellulose (NaCMC) that forms clear solutions in water at all temperatures, has exceptional water binding properties, and is available in a wide range of viscosity grades. Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose using a Waring Blender. FMC Corporation: Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations DE102009022738A1 (de) * 2009-05-26: 2010-12-09: J. Rettenmaier & Shne Gmbh + Co. Kg . Microcrystalline Cellulose. The charts below provide guidance on how to select and use standard and co-processed grades of Avicel Microcrystalline cellulose in pharmaceutical products. Date Approved: 05/25/2010. Wu, K. Zuurman, H.W. Currently, it is marketed both directly and indirectly (through distributors) depending on the country in question. <> Looking for FMC'searnings news? A schematic illustration of the manufacturing process for Avicel Microcrystalline cellulose is shown below. Thus, Avicel contributes no or very few calories to the food system. 4. CAS 9004-34-6, pH 5 - 7.5. Request media, explore upcoming events and read our latest updates. 1.3. Co-processed excipients deliver functional synergies to address formulation challenges with simplified, single ingredient solutions. Molecular weight: Not Applicable 1.5. Alginate drug delivery harnesses the unique properties of seaweed for premier performance in multiple pharmaceutical and nutraceutical applications; they impart viscosity in solutions and even form a three-dimensional gel in the presence of calcium ions. Their nomenclature and recommended applications are shown below: Co-processed Avicel grades are high functionality materials designed to bring added performance over and above what standard grades offer. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Alginates also function as actives in some anti-reflux products. Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses CN103842425B . Microcrystalline cellulose has excellent compressibility properties and is widely used in solid forms such as tablets that are hard, but can dissolve quickly, and this has increased its demand in . Innovation is at the heart of IFFs purpose of applying science and creativity to create a better world. Combinations of microcrystalline cellulose (MCC) and sodium carboxymethyl cellulose (Na-CMC) are commonly used as stabilising agents and suspending agents in pharmaceutical formulations. <> Avicel is a brand name by Dupont for grades of Microcrystalline cellulose. Microcrystalline Cellulose / Avicel PH-102. Gloves, eye protection and a dust mask should be used. The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. Kristensen, T. Schfer, P. Kleinebudde, Direct pelletization in a rotary processor controlled by torque measurements. !,K`I[O@U|$+i 8sB|+"B@'2^7[2XKrd#5b /Group << /S /Transparency /CS /DeviceRGB /I false /K false >> No. METHOCEL cellulose ethers are water-soluble polymers derived from cellulose. They are soluble in a wide range of organic solvents, beginning with aliphatic alcohols such as ethanol and isopropanol, and are compatible with most other familiar organic solvent chemistries, including ether alcohols, ketones, aromatic hydrocarbons and many more.
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